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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2B
All Species:
30.3
Human Site:
S1550
Identified Species:
47.62
UniProt:
Q02880
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02880
NP_001059.2
1626
183267
S1550
G
A
K
K
R
K
A
S
G
S
E
N
E
G
D
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
S1558
G
A
K
K
R
K
A
S
G
S
E
N
E
G
D
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
S1544
G
A
K
K
R
K
A
S
G
S
E
N
E
G
D
Dog
Lupus familis
XP_534241
2041
231068
S1966
G
A
K
K
R
K
A
S
G
S
E
N
E
G
D
Cat
Felis silvestris
Mouse
Mus musculus
Q64511
1612
181890
S1537
G
A
K
K
R
K
A
S
G
S
E
N
E
G
D
Rat
Rattus norvegicus
P41516
1526
173202
A1456
K
K
P
A
P
A
K
A
K
N
S
R
K
R
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507216
1923
216719
S1849
G
A
K
K
R
K
A
S
G
S
E
N
E
G
E
Chicken
Gallus gallus
O42131
1627
183228
S1553
G
A
K
K
R
K
T
S
G
S
E
N
E
G
E
Frog
Xenopus laevis
NP_001082502
1579
178601
K1509
S
K
A
T
K
Q
Q
K
R
K
N
S
D
S
D
Zebra Danio
Brachydanio rerio
NP_001038656
1618
182448
S1542
R
S
K
K
R
K
Q
S
S
L
E
E
D
E
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
E1377
S
S
L
F
S
D
E
E
E
D
G
G
N
V
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
S1450
P
K
T
A
E
P
K
S
K
A
V
T
D
F
F
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
D1378
W
S
D
T
E
S
E
D
E
H
L
D
D
V
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
V1403
F
N
K
K
S
S
S
V
M
S
R
L
A
D
N
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
L1358
E
L
S
G
E
S
D
L
E
I
L
D
S
Y
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.3
98.5
78.1
N.A.
95.6
66.2
N.A.
79.3
89.2
66.6
73.6
N.A.
50.3
N.A.
49.5
57.3
Protein Similarity:
100
98.5
99.1
78.8
N.A.
97.2
78.1
N.A.
81.8
93.8
78.7
83.8
N.A.
64.3
N.A.
65.8
69.9
P-Site Identity:
100
100
100
100
N.A.
100
0
N.A.
93.3
86.6
6.6
40
N.A.
0
N.A.
6.6
0
P-Site Similarity:
100
100
100
100
N.A.
100
20
N.A.
100
93.3
33.3
53.3
N.A.
6.6
N.A.
20
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.3
40.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59
56.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
47
7
14
0
7
40
7
0
7
0
0
7
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
7
0
0
7
7
7
0
7
0
14
27
7
40
% D
% Glu:
7
0
0
0
20
0
14
7
20
0
54
7
47
7
14
% E
% Phe:
7
0
0
7
0
0
0
0
0
0
0
0
0
7
7
% F
% Gly:
47
0
0
7
0
0
0
0
47
0
7
7
0
47
7
% G
% His:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% I
% Lys:
7
20
60
60
7
54
14
7
14
7
0
0
7
0
0
% K
% Leu:
0
7
7
0
0
0
0
7
0
7
14
7
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
7
% M
% Asn:
0
7
0
0
0
0
0
0
0
7
7
47
7
0
7
% N
% Pro:
7
0
7
0
7
7
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
7
14
0
0
0
0
0
0
0
0
% Q
% Arg:
7
0
0
0
54
0
0
0
7
0
7
7
0
7
0
% R
% Ser:
14
20
7
0
14
20
7
60
7
54
7
7
7
7
0
% S
% Thr:
0
0
7
14
0
0
7
0
0
0
0
7
0
0
14
% T
% Val:
0
0
0
0
0
0
0
7
0
0
7
0
0
14
0
% V
% Trp:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _